Cell biological consequences of Leigh syndrome
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The Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovary Polycystic Ovarian Syndrome in Rat
Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder in which thelevel of oxidative elements in blood rises. Green tea is a potent antioxidant since it containscatechins. In this study, the effect of hydro-alcoholic green tea extract on PCOS rats was examined.For PCOS induction, 96 mature Wistar rats were given estradiol valerate. After 60 days, therats were divided into fo...
متن کاملThe Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovary Polycystic Ovarian Syndrome in Rat
Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder in which thelevel of oxidative elements in blood rises. Green tea is a potent antioxidant since it containscatechins. In this study, the effect of hydro-alcoholic green tea extract on PCOS rats was examined.For PCOS induction, 96 mature Wistar rats were given estradiol valerate. After 60 days, therats were divided into fo...
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Human complex I (NADH:ubiquinone oxidoreductase; EC 1.6.5.3) is the first and largest multi-protein assembly of the mitochondrial oxidative phosphorylation (OXPHOS) system; the final biochemical cascade of events leading to the production of ATP. The complex consists of 46 subunits, 7 encoded by the mitochondrial DNA and the remainder by the nuclear genome. In recent years, numerous gene mutati...
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A decline in mitochondrial respiration represents the root cause of a large number of inborn errors of metabolism. It is also associated with common age-associated diseases and the aging process. To gain insight into the systemic, biochemical consequences of respiratory chain dysfunction, we performed a case-control, prospective metabolic profiling study in a genetically homogenous cohort of pa...
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in the mitochondrial DNA (mtDNA) that lead to oxidative phosphorylation impairment, ATP depletion, cellular dysfunction, and ultimately cell death [1]. Most mitochondrial diseases involve impairment of multiple organs, particularly in tissues with a high energy demand such as nerve and muscle. Identification of causative mutations in patients with Leigh syndrome and MERRF by mitochondrial DNAta...
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